Having worked alongside several "older" Eastern European Jewish folk, I try not to make light of the latter half of that word.  That aside...............

I guess it depends on the context.  Right or wrong, it doesn't hit me in the same way when a woman uses it, because it doesn't leave quite as icky a feeling in my head.  There's not the same "how-dare-you-not-submit-to-the-superior-gender" air to it.  I suppose it could be used effectively in an ironic or sarcastic way, but I think most uses of it are performed on a much lower level.